Wednesday, February 29, 2012

A closer look at the Samsung Galaxy Note 10.1 (video)

The last time we showed you the Galaxy Note 10.1, we had time for a few hands-on shots, but not quite enough to get to know the tablet, to warm up to the idea of interacting with one of our favorite 10-inchers using a stylus pen. Now that we've had a chance to park ourselves at Samsung's Mobile World Congress and get acclimated to the various S Pen apps, we wanted to hit back with one more hands-on, this time focusing on what makes the Note 10.1 so special: the writing experience. Meet us past the break and we'll share some early impressions, along with a walk-through video. Only have a minute to spare? Consider those photos below your Cliff's Notes.

Continue reading A closer look at the Samsung Galaxy Note 10.1 (video)

A closer look at the Samsung Galaxy Note 10.1 (video) originally appeared on Engadget on Tue, 28 Feb 2012 18:40:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/02/28/a-closer-look-at-the-samsung-galaxy-note-10-1-video/

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Tuesday, February 28, 2012

French President Sarkozy Is On Pinterest. Well, Maybe.

313px-Flickr_-_europeanpeoplesparty_-_EPP_Summit_October_2010_(105)Typically, when I think of an "early adopter," French President Sarkozy doesn't come to mind. The man who announced his intention to run for reelection on February 12th didn't even have a verified Twitter account prior to that date. Fortunately for him and his campaign, he now has a verified account with over 97K followers. He has even made it clear that he signs his own tweets with NS.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/95oEkYVw_A4/

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Sunday, February 26, 2012

Renting Homes Requires Research Too! | The Real Estate Briefings

The down turn in the housing market has resulted in a lot fewer people being able to qualify for mortgages. Five years ago nearly everybody that applied for a mortgage was granted one. Today, the banks and mortgage companies are being much more cautious, and as a result, many people are finding that renting homes and apartments is their only option.

Renting homes is very similar to buying in regards to researching the areas and prices that might interest a renter. There are lots of websites that focus on renting homes and other resources that can be very informative for a renter. It is important that this research is thorough because although renting a house is not as permanent as buying a home, but it can still be an expensive mistake if a renter is unhappy.

The initial expenses when renting homes can add up. A landlord will generally require the rental payment for three months up front. This is for the first month payment, the last month payment and a security deposit. They will also usually require a pet deposit, if a pet will be moving in with the renter. There is also the cost of the actual move; this could include movers, boxes, packing materials or truck rentals. These expenses can really add up if a renter does not perform the proper research and has to move again months later.

Whether a person is planning to buy or rent, research is the key to a smooth move. Many feel that when renting homes they can just take a quick look around and move. This can be a huge mistake for a renter?s mental health if he or she later finds the home or location is unacceptable. Although not as permanent as buying, renting a home can be a very important step in a person?s life. Research will ensure a smooth move in this big step.

Related posts:

  1. Renting A Home That?s In Foreclosure
  2. The Negative Effects Of Renting A Home
  3. Renting Wisely and Buying Smart
  4. A Market Ready to Move ? The Research Triangle
  5. Renting with the Landlord Right Upstairs

Source: http://www.realestatebriefings.com/renting-leasing/renting-homes-requires-research-too/

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Faxless Quick Fast payday loans ? Acquire Instant And prepared ...

To meet up with the growing demands of a typical person, you are able to make the aid of faxless 24 hour payday loans online. You are able to claim that loans provide the perfect tool to rearrange for finances. It?s a common perception some of the folks loans cannot support in meeting emergency requirements. But by availing this facility of loans, you are able to solve all his financial blues. This thinking is really with thanks to the conisder that the mortgage approval needs time to work. Payday cash advances are customized to ensure the people could from their financial problems. By availing choices, you are able to avail immediate cash. The advance amount becomes approved within 24 hours.

Faxless 24 hour payday loans online are typically good for the salaried class people like they want to conserve a monthly budget along with have adequate funds to get to know the emergency requirements. Faxless 24 hour payday loans online can be to get to know nearly every financial needs like paying for wedding expenses, home repairs, medical bills, paying to have a holiday etc. Payday cash advances don?t require any collateral for being pledged with amount of the loan. Thus, this loan facility is a form of unsecured loan facility. It?s a without risk loan facility. But this generally not very considerably the borrower maintain a pool of ability to forgo the mortgage amount. They could arrive at a legal court with the lender. The lending company can file a lawful complaint against him which enable it to take strict action.

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Under faxless 24 hour payday loans online facility, one dosen?t really have to fax the documents. From the loan is commonly of unsecured type, you have to of valuation also. Thus the mortgage approval takes a shorter period. Before you apply on the loan facility, you must instigate a proper research over the web in connection with lenders giving the amount of the loan facility. You are able to compare the offers made available from them under similar conditions and judge the perfect. By doing the learning over the web, you are able to save both a serious amounts of efforts. It?s a straight forward option while there is you don?t have to have paperwork done. You are able to simply download the approval of this website and merely grow it. The approval isn?t hard to check out and understand. It takes certain details for being filled like name of this borrower, his contact address, income and employment status. Thus, to your house . really wants to meet temporary financial emergency, he then may aid from faxless same payday loans online facility.

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When an unexpected emergency strikes, you need coaching and require to help fast, before it?s in its final stages to attempt anything relating to this. A fiscal emergency provides similar requirements, wherein, you absolutely need immediate funds to get to know the urgent requirement who may have cropped up. Virtually anyone would start looking along the easiest choices to him, when buying immediate tax assistance. This option could be asking a mate or significant other to be lent money. However, firstly, it?ll be embarrassing to divulge your financial status towards a known person. And secondly, a man you method for help may possibly the desired funds at his disposal, thus, not be able to help you financially.

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This article was written by Borbar Woderle

Source: http://www.blogsvalencianistes.com/faxless-quick-fast-payday-loans-acquire-instant-and-prepared-finance/

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Saturday, February 25, 2012

The Engadget Interview: BlackBerry PlayBook product manager Michael Clewley

There's no getting around it: it's been a rough couple of years for Research in Motion. This week's on-time release of its PlayBook 2.0 software marked a rare bright spot in an otherwise grim era, bringing much needed features for the QNX platform such as a unified inbox, deeper social integration and updates to the company's BlackBerry Bridge app.

At the same time, the release of the 2.0 software has brought many of our outstanding questions to the fore: why weren't these features present in the first go-round? Why did the company take so long to flesh out its software? And lastly, when will we see some proper second-gen hardware? We sat down with PlayBook product manager Michael Clewley to discuss the slate's ups and downs, and how the revamped tablet stacks up in an increasingly crowded field.

Continue reading The Engadget Interview: BlackBerry PlayBook product manager Michael Clewley

The Engadget Interview: BlackBerry PlayBook product manager Michael Clewley originally appeared on Engadget on Thu, 23 Feb 2012 20:00:00 EDT. Please see our terms for use of feeds.

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Colonoscopy Prevents Death, a Study Affirms

[unable to retrieve full-text content]Although many people have assumed the cancer screening must prevent deaths because it is so often recommended, strong evidence had been lacking.

Source: http://feeds.nytimes.com/click.phdo?i=abc2e61b979008209f34d88935c09277

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Friday, February 24, 2012

Peru Travel And Leisure: The Hard Route To Machu Picchu | Learn ...

Although some travelers might not enjoy or feel with booking packaged tours in their trips, there are clearly some situations in addition to activities in Peru in which a hired guide and / or group trip is strongly recommended. Eventually the Moche the world would extend within the Piura River during northern Peru in the Huarmey River a good deal further south utilizing their capital Chan Chan founded in your Moche valley by itself. Along the shore, fish was obviously a frequent product. These are real wood boxes divided in two a couple of levels and filled with hand painted picket figures. Sanguches (sandwiches) are factors behind type of rapidly, on-the-go food, and Peruvians don?t believe twice about dipping proper bodega or purchasing one from a avenue cart. This colonial city provides a chill vibe including a wonderful warm dry climate providing a sense connected with calm and relaxation while you arrive. For smaller crowd, the low holiday season between Sept and April is best. Was it a purpose of pilgrimage, an astronomical observatory and more or less everything at once? The exterior walls made metropolis so impregnable that even though a lengthy 10 yr war, the only means the Inca?s were efficient at conquering the place was to finally cut-off water supply by means of breaking the aqueduct system that were built to provide water for the farms and urban center. Viajes a Peru

Can one look for a whole ?forgotten? city from the 21st century? Although many persons are happy with the center option (the particular Vistadome train), if you?re truly searching for a luxury experience, take the Hiram Bingham work out. Whether you reach sunrise when that morning mist continues to be trying to get up, or in the afternoon if the sun is hitting down at a hardest, the view with the archeological site is usually regarded among the most beautiful on this planet, and has even been considered to be a spiritual encounter. It was your Incas who created the famous along with beautiful Machu Picchu internet site, which still is situated today, unspoiled, upon lush mountain / hill peaks. The sanctuary lodge is found at the appearance to Machu Picchu and unique lunches with the Tampu restaurant fo you to eat peacefully. However, in all the particular churches was song, whether of human body or voice. But still no-one knows which theory may be the true one. Trekking in Peru, most notably Machu Picchu, is stunning. Turismo Peru

Paracas is a destination in Peru regarding nature lovers as well as bird watchers. If you first getting in Lima, take a flight towards city of Cusco that should take only 1 hour in contrast to almost 22 working hours by bus. In contrast in the coast, which receives minor rain at virtually all, the sierra has a whole lot during the rainy season the fact that the famed Inca Walk near Cusco is closed per year during February! The blue waves of this Pacific are ideal for surfing or just enjoying through the beach. If you?re up for your challenging hike, try to go before that takes place. I am grateful to have in this abundant world stuffed with many people and far life with whom We are connected. During this period, the river amounts dip and roads are basic drive. Ballesta Islands is often a protected nature spot for animals including sea lions, penguins, birds, and turtles. The capital, Lima, known as the town of Kings carries a population of more than 8 million folks and was created by Francisco Pizarro with 1535. This is an attractive demanding environment, so most travelers would want to travel here during a guided head to package. Machu Picchu

Tags: Machu Picchu, Tourism, Tourism to Peru

Source: http://emilycmorgan.com/peru-travel-and-leisure-the-hard-route-to-machu-picchu/1938/

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Pitcher Yu Darvish gets going at last with Rangers

By JANIE McCAULEY

AP Baseball Writer

Associated Press Sports

updated 3:01 p.m. ET Feb. 23, 2012

SURPRISE, Arizona (AP) -The Texas Rangers would love to hear Yu Darvish's best go at "y'all."

"Some Texas twang, any type of slang," said fellow starter Colby Lewis, who spent time pitching in Japan in the opposite division as Darvish. "He'll have fun. It's going to be good."

Give him a little time, gang. Darvish most certainly would prefer to show off his powerful arm and remarkable athletic abilities before he delves into learning the lingo of the Lone Star State or belting out "Deep in the Heart of Texas."

Darvish, with his shaggy, orange-tinted hair and a dark goatee, pulled a blue long-sleeved Rangers workout shirt over his head Thursday and chatted up teammate Justin Miller as nearly everybody in the clubhouse eagerly watched. At 6-foot-5, he's quite a presence even before considering that the Rangers spent more than $107 million this winter to land him.

Texas will be dealing with some "Yusanity" this season.

"I guess this comes with success and all that," manager Ron Washington said Thursday, before taking the field to watch Darvish himself. "People are interested in the Texas Rangers so I guess we just have to deal with it."

The team's prize offseason pickup looked plenty comfortable in his new surroundings on the first day for pitchers and catchers at Surprise Stadium, where dozens of Japanese reporters arrived early to record the right-hander's every move.

No question his fame reaches cult status.

Fans lined the area around the bullpen to catch a glimpse and autograph hounds were relentless in their efforts, swarming until a claustrophobic circle formed around the pitcher as he wrapped up his work day. Darvish received a police escort between practice fields.

"I directed traffic," joked pitching coach Mike Maddux. "It's a little postseason pandemonium here in spring training. A lot of guys are well known. Sometimes you run into somebody who's famous. That's what we're dealing with, someone who's famous."

Texas personnel provided a detailed schedule for the star Japanese pitcher's highly anticipated first day: from when and where he would stretch and warm up to his first fundamental drill and then his initial bullpen session.

Darvish threw for five minutes in the bullpen followed by five minutes on the mound against live hitters, throwing 19 pitches during that session against a pair of minor leaguers - tossing an array of fastballs to both sides of the plate, sliders, curveballs, changeups and even one split-finger.

Catcher Mike Napoli asked to catch Darvish on Day 1, when slugger Josh Hamilton also was out on the field and signing autographs.

"I'm just excited to get the chance to see him pitch for the first time aside from the footage on ESPN," new Rangers reliever Joe Nathan said. "His work ethic seems to be outstanding. We had a chance to talk yesterday. He enjoys getting in the weight room as much as he enjoys pitching. That will help him pitch a long time and he should adjust a lot quicker."

Darvish's father, Farsad, is in the Arizona desert to help his son through that process. The baseball part of Darvish's life will take care of itself, his father said.

"He seems to be doing OK," the elder Darvish said. "I don't really talk to him about his baseball career. That he gets adjusted and used to the culture is my concern. He's been in the big leagues in Japan and gets a lot of attention, so to him this is normal."

The two-time reigning AL champion Rangers don't envision communication problems with the 25-year-old Darvish, and Washington has no plans to learn Japanese - for one, he doesn't see it fitting it into his already hectic spring schedule.

"I don't want to trash the language," Washington quipped. "I'll use my universal baseball language. I trash the English language."

Washington won't say what day Darvish will first pitch in Cactus League action or guess how many wins he will earn as a rookie. There will be huge expectations given he signed a $56 million, six-year contract and the Rangers paid his Japanese club $51.7 million just to have the chance to acquire him.

"I think we're all excited about seeing him throw, watching him do his work," Rangers president and CEO Nolan Ryan said. "I think watching video on him I have an expectation of what he's going to be like so I don't think it's going to be really much different from what I've seen in the videos of him. But you know just seeing his delivery, watching him from different angles and that kind of stuff. Obviously everybody that's been involved in this process is anxious to see that."

The brass lined up behind the fence to observe Darvish's initial session. He impressed all right - and he was only going at 80 percent according to Napoli and the pitching coaches. When he faced top prospect Jurickson Profar and Ryan Strausborger the protective L screen stood right in front of the mound as a precaution.

Napoli gave Darvish a high-five and a hug after they were done.

Seattle resident and Mariners fan David Duggan showed up Thursday with Darvish's World Baseball Classic jersey hoping to get it signed for his 20-month-old daughter, Hannah.

"When Ichiro came I didn't realize the magnitude of it," Duggan said. "This could be like Ichiro mania or Dice-K mania."

Darvish's routine has been carefully mapped out. He will throw every other day and pitch in an intrasquad game on Day 9.

"He handles himself well," Maddux said. "He was there and eager to go. He didn't want to wait to throw. That's refreshing."

----

AP Sports Writer Bob Baum contributed to this story.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Braun wins appeal of suspension

??HBT: Reigning NL MVP Ryan Braun wins the appeal of his 50-game drug suspension, which is great news for him and the Brewers. Meanwhile, Major League Baseball "vehemently" disagrees with the ruling.

DeMarco: Diamondbacks are here to stay

DeMarco: There is plenty of evidence that the Diamondbacks have set themselves up nicely for a short-term run of success ? no matter how much their win total may fall in 2012.

Source: http://nbcsports.msnbc.com/id/46499744/ns/sports-baseball/

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Thursday, February 23, 2012

Wednesday, February 22, 2012

Raising and Improving Windows 7 Speed and Performance

Operating faster than every other Windows system, Windows 7 is in a class by itself. In order to achieve optimal speeds with your computer, you need to do a few things to make this happen. By making small changes, your computer can run even faster using the Windows 7 operating system ? here are a few tips.

There are several disagreements across the Windows 7 arena in regard to what will actually make this OS run more smoothly and quickly. One thing that people do is talk about whether increasing the number of cores can actually increase processing speed. You may find instructions that tell you to go to advanced options and change the number of processors that the system is using. Boot time will not increase, however, if you change the initial processors because it is already set to the maximum amount automatically in its configuration. Overall, it is worth a test, even if most people believe that it will not improve the speed of your system. Active Desktop is a feature that some people like, but if you don?t use it, you may want to disable it. If you like to be able to view your favorite web pages from your desktop without having to even click on your browser, then you should keep Active Desktop working. It?s up to you to decide whether features such as this are worth having, or if making Windows 7 faster is more of a priority. You might have a reason to want to view a particular web page instantly, but most users probably wouldn?t miss this. There are other ways to bring up sites rapidly -make one your home page, bookmark any others. Another way to free up RAM and speed up Windows 7 is to set your desktop background to a solid color. You have several options when you click on Desktop, and when you choose personalize you can choose your colors. Measures like choosing a solid color will probably speed up your computer a bit, and when combined with other changes, you?ll notice a real difference.

Just a brief side note ? if you would like read more about this, have a look at this blog: the magic of making up reviews

You can speed up Windows 7 quite a lot by turning off some of the features that you aren?t going to be using often. You can, to use one example, to into System Properties and turn off a lot of the visual effects that slow down your computer. This might make your desktop slightly less flashy but you won?t be turning off any graphics that do essential things. Another feature that many users don?t need is Remote Assistance, which can also be disabled under Systems Properties. There are probably other features that you can turn off as well, depending on what you normally use. For example, you can switch your Help and Support to the manual mode so that it doesn?t automatically start up when you start up your computer. You can speed your Windows 7 OS up dramatically by following these suggestions. The system is actually very fast comparatively speaking and by doing just a couple things, it will run even faster. Programs that you don?t use on a regular basis can be removed with no problem at all. This article was created to help you speed your computer up with tips that we also have used.

Source: http://27rue.com/raising-and-improving-windows-7-speed-and-performance/

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Bullish hedge funds hike their bets in 2012 rally (Reuters)

[unable to retrieve full-text content]Reuters - Hedge funds are cranking up their bets in equities and credit in 2012's buoyant markets in the belief that the euro zone, U.S. and Chinese economies will fare better than many were fearing last year.

Source: http://us.rd.yahoo.com/dailynews/rss/economy/*http%3A//news.yahoo.com/s/nm/20120220/bs_nm/us_hedgefunds_risk

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Tuesday, February 21, 2012

Microsoft Nails Down Windows End-Of-Life Dates

medium_3419565232Still using Windows Vista? XP? Why? Well, whatever the reason, Microsoft has clarified some of their end-of-life dates for older versions of Windows, including XP. This is mostly about support on the business side but it could be useful if you've got an old machine that's acting up (or you refuse to upgrade).

Source: http://feedproxy.google.com/~r/Techcrunch/~3/3u38POv2PcQ/

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A Little Effort for Better Fitness Begins with Wonderful Assistance ...

You are here: Home / Physical Fitness / A Little Effort for Better Fitness Begins with Wonderful Assistance






In today?s busy world, staying fit and healthy can seem like an impossible task. It doesn?t have to be that way. You can find any numbers of remarkably straightforward ways you can your self straight into great shape and never have to eliminate on your own. The tips in this article will help you on your way.

Aerobic fitness exercise is incredibly beneficial for people that have problems with high blood pressure. A power walk or 45 minute jog can help to lower blood pressure for as much as 24 hours. Obviously, some people can?t manage 45 minutes to begin with, so start with a lesser amount of time and work your way upwards. If you don?t appreciate aerobic fitness exercise, resistance training can also help to regulate high blood pressure.

Before using any bench to workout, give it a test. You should press your thumb into the bench seat to test the padding the bench is made of. When you can glance at the wood or metal under the regular, then you definitely needs and locate one more seats.

If you?re attempting to lose weight so that you can boost your fitness level, then you need to can remember the significance about be a cheater times. While you generally want to stick to your diet, it is important to give yourself some days of flexibility so that you can really fulfill a craving! Just don?t overdo it either.

Gardening is a great way to improve your health. Playing in the dirt can improve your overall fitness step as well as your functional strength. While it?s an excellent activity, you ought to health supplement your gardening workout routines along with strength training as well as cardio workouts. Be careful while gardening, don?t strain your back.

Intelligent health and fitness buffs don?t subject on their own in order to lengthy groups of abs crunches or perhaps sit-ups each day. The abdominal muscles that these exercises target are like any other set of muscles: They respond best when they get time to recover following a workout. The best results come from limiting abs workouts to two or three sessions a week.

Shoes must provide the proper support for your feet and therefore the rest of your body. Worn out shoes can increase the stress on your limbs, causing problems over time. Ensure you hold the appropriate support inside your shoes, especially in the course of workout. This also minimizes the risk of other injuries too.

It is best to not workout on an empty stomach. Your body needs fuel, particularly if you are putting it through a grueling and sweat-inducing workout. Gas high on excellent, healthy food that will provide the vitality you should get by your exercise plus your body may thank you.

When you begin fitness training you should focus on developing the habit of training more than the training itself. Set up a specific time to train each day and devote that time to training activities. It does not have to be a long time ? 15 minutes will do. The activities do not have to be difficult ? a walk will do. Just establish the habit firmly.

Getting in shape doesn?t have to be a time-consuming ordeal. It?s not as difficult as you might think to change your routine to include more exercise. Just use exactly what you?ve got learned from this article as well as before long, you will end up soon on your way finding yourself in the most effective form of your daily life.

Karen Wiseman is an expert on physical fitness and that is why she owns a fabulous body. She knows what she is talking about to be in fit. Just take a look here: http://pull-up-bar-reviews.com/category/fitness-step http://pull-up-bar-reviews.com/fitness-step/understanding-the-importance-of-getting-the-right-home-fitness-equipment


Source: http://www.ahipbelieves.com/physical-fitness/a-little-effort-for-better-fitness-begins-with-wonderful-assistance/

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Monday, February 20, 2012

Traitorous immune cells promote sudden ovarian cancer progression

ScienceDaily (Feb. 20, 2012) ? Aggressive ovarian tumors begin as malignant cells kept in check by the immune system until, suddenly and unpredictably, they explode into metastatic cancer. New findings from scientists at The Wistar Institute demonstrate that ovarian tumors don't necessarily break "free" of the immune system, rather dendritic cells of the immune system seem to actively support the tumor's escape. The researchers show that it might be possible to restore the immune system by targeting a patient's own dendritic cells.

"Our model shows where the cancer is kept in check for relatively long periods, but once they become noticeable, tumors grow exponentially," said Jos? R. Conejo-Garcia, M.D., Ph.D., an associate professor at Wistar and leader of the Tumor Microenvironment and Metastasis Program of Wistar's Cancer Center. "More importantly, we show that by depleting these dendritic cells of the immune system, we can reverse the effect, once again allowing our immune system to recognize the ovarian tumors."

Their findings, presented in the March issue of the Journal of Experimental Medicine, available online now, represent the first successful attempt to model the tumor microenvironment of human ovarian cancer in a mouse model of the disease. In essence, the model replicates the inflammatory surroundings that ovarian tumors experience in humans. The more accurate model provides a better tool for researchers to understand, prevent, and treat tumors.

"Our system uses oncogene-driven tumors that are spontaneously antigenic, thus avoiding the use of artificial foreign antigens that do not accurately replicate what drives anti-tumor immune responses in humans," Conejo-Garcia said.

Ovarian cancer remains one of the most deadly forms of cancer in women. According to the National Cancer Institute, 21,990 women will be diagnosed with ovarian cancer, and 15,460 women will die of the disease this year. Because early-stage ovarian cancer does not often exhibit noticeable symptoms, many women are not diagnosed until the cancer is at a later stage, when it is most difficult to treat.

"While we have seen an increase in survival rates for most cancers over the last 40 years, ovarian cancer survival has only improved slightly since the 1970s," Conejo-Garcia said. "We created our ovarian cancer model to get a better understanding of how these tumors acquire such aggressive characteristics and evade the immune system."

According to Conejo-Garcia, their model demonstrates how a localized ovarian tumor flares into an aggressive metastatic disease.

"You can see where, if one ovary is cancerous, it is almost unrecognizable until an instantaneous moment, when it explodes into exponential growth," Conejo-Garcia said. "The key to this moment, our evidence suggests, is in the phenotypic changes taking place in the dendritic cells that are part of the tumor microenvironment."

In healthy tissue, dendritic cells function as sort of alarm system to alert the adaptive part of the immune system to potential threats. They work as antigen-presenting cells, offering foreign or disease-causing molecules (called antigen) to the white blood cells that can then respond to an infection or, in this case, tumorous growths. Amid the ovarian cancer microenvironment, dendritic cells also induce the immune system to attack tumor cells and inhibit their growth.

Until, that is, dendritic cells seem to switch sides.

"We see a change in the dendritic cells themselves, which allows tumors to progress to terminal disease in a very short time," Conejo-Garcia said. "Interestingly, the tumors themselves are still immunogenic -- they could still otherwise elicit an immune response -- it is just that the dendritic cells are actively suppressing the involvement of other anti-tumor immune cells; primarily T cells."

Conejo-Garcia and his colleagues believe that their findings offer a twist on the emerging theory of "cancer immunoediting." The immunoediting hypothesis suggests that the immune system actively "edits" tumor cells to eliminate antigens that are recognized by immune cells, keeping the cancer at bay before it becomes symptomatic. All symptomatic tumors, therefore, represent a failure of the immune system, where tumors lose their immunogenicity -- their ability to trigger and be recognized by our immune system.

The researchers found that depleting dendritic cells early on accelerating tumor expansion, while removing dendritic cells later on actually delayed the tumor's progression. According to Conejo-Garcia, their findings suggest it is a change in the immune system itself, specifically the dendritic cells, and not primarily any loss of immunogenicity on the part of the tumor.

"It is almost as if anti-tumor T cells become exhausted, they can no longer keep up the effort," Conejo-Garcia said. "Still, our findings suggest that the enduring activity of these T cells would allow us to control metastatic ovarian cancer by targeting the dendritic cells that actively prevent their anti-tumor functions."

In fact, Conejo-Garcia and his colleagues have already developed a strategy to reprogram traitorous dendritic cells. In a an upcoming edition of the journal Cancer Research, available online now, the researchers demonstrate how synthetic RNA molecules can be used to win back the allegiance of dendritic cells and restore their ability to stimulate tumor suppression.

Funding for this research was provided through grants from the National Cancer Institute and the Department of Defense.

The lead author of the study is Uciane K. Scarlett, Ph.D., a staff scientist in the Conejo-Garcia laboratory. Wistar co-authors also include Melanie R. Rutkowski, Ph.D. and Ximena Escovar-Fadul. Co-authors from Darmouth Medical School include Adam M. Rauwerdink, Ph.D., Jennifer Fields, Jason Baird, Juan R. Cubillos-Ruiz, Ph.D. (currently at Harvard University), Ana C. Jacobs, Jorge L. Gonzalez, M.D., John Weaver, Ph.D., and Steven Fiering, Ph.D.

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Story Source:

The above story is reprinted from materials provided by The Wistar Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Uciane K. Scarlett, Melanie R. Rutkowski, Adam M. Rauwerdink, Jennifer Fields, Ximena Escovar-Fadul, Jason Baird, Juan R. Cubillos-Ruiz, Ana C. Jacobs, Jorge L. Gonzalez, John Weaver, Steven Fiering, and Jose R. Conejo-Garcia. Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. Journal of Experimental Medicine, 2012 DOI: 10.1084/jem.20111413

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/02/120220102144.htm

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Sunday, February 19, 2012

Early Childhood Education

early childhood education the term used to describe the formal education and care for other members of his family or children outdoors. Home

planning purposes, it decided to extend the concept of early childhood education, about eight years. This age group is an opportunity to strengthen Hong Kong as a continuous development of the view. This will facilitate the interaction between the kindergarten and primary school. The concept of the quality of basic education, early childhood education and key ?survival? needs, the primary one two or three years.

Terms of preschool and kindergarten emphasized that the age of 3-6 years of education. ?Learning Early Childhood Education?, ?early treatment? and ?child? in early childhood education programs.

nursery and children who do not belong to the terms of the education. Many childcare centers are a variety of ways. Create a curriculum to fit their daily work to improve learning and education. For example, the

children the difference between care and kindergartens, education, almost gone, the country needs a teacher in a variety of early childhood education institutions, staff of the Children?s Parliament held in early childhood education at the national level, said, though it may be the main objective of education for children of all early childhood education programs, improving the overall quality to ensure that the high level of care and training of young age and for children?s physical and emotional needs.

but the support necessary to distinguish between related to learning and locomotives. a basic instrument characteristics of a child?s development, the second refers to hand-eye coordination. the

as a parent, you probably have many questions, such as early childhood education means what? Why do the children need to learn the ?early? and to help those in school, and grow in life?

According to Dr. James Heckman won the Nobel economics economics educational development of children early human experience is the foundation for future learning early learning to create more learning. ?

If you are what you get in the soil and planting, plant seeds, is a solid the foundation, able to withstand the tree. The human potential is to be if you want to establish a better future for your children, in the future development to maintain the necessary skills to develop and maintain at an early stage.

early education of children and more researchers. The interaction between the children will be taught at the division, in the alternative, friends, develop their own language and arithmetic. Estimated 3-year-old children to collect and set aside ? he Ideally, pre-school class, things arranged so that children can be the things they need to start the game or games after the completion of a project / project. Is complete, you can find these things come back. In short, early childhood education should receive adequate training, including disability component.


early childhood education is a long-term use to describe the formal teaching and child care than other families. Learning time of the site, to provide children with early childhood education. For more information, please visit http://www.learningtimenow.com/


Find other articles the childhood

Source: http://www.onecoldhand-nyc.com/early-childhood-education

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Setting Goals Is The Key To Successful Self Improvement | Javier ...

Pursuing your personal development could be a great encounter that helps you feel much more in manage of your own life. To keep your motivation up, you ought to seek out some ideas for inspiration. This post contains helpful information and ideas to assist you get a far better understanding of personal development.

Writing out your objectives will help you create your personal program for private growth. If you are looking for confidence, for instance, write that down as a goal. You then want to think of various items you can do to boost in that region, so for confidence you?d want to locate methods to be much more confident. Lastly, seek out scenarios where you can implement those actions. This approach will increase the likelihood of the good results.

To be an successful leader, you need to combine humility with energy. There?s an element of service that makes up the character of a leader, as it enables them to lead with gentleness. A actual leader will practice integrity, and uphold a strong sense of morals. These are all items that one particular must have to be a productive leader.

Do you consume an excessive amount of alcohol? Are nicotine or other destructive habits something that harms you? You need to treat your body like a temple, since that is what it?s. 1 method to improve your life is by obtaining rid of any poor habits that you simply have. Have a look at how you?re living your life, and check in the event you are participating in any negative habits that should be eliminated.

Look for your internal beauty, instead of your external look. Your hair, clothing, and complexion will not be the most essential things about you. Your personality and capabilities are what will get you via life. It is as a result best to perform on enhancing your internal self instead of wasting time and cash on superficial improvements.

Stop stressing the small stuff. Worrying is just focusing on one thing that hasn?t happened and letting your fears take over. As an alternative, think about what the worse case scenario could be and program how you?d cope with it. Becoming prepared gives you the freedom to enjoy your life a lot more fully.

The majority of employers that you simply encounter will not care regarding the school you graduated from. They care about how effective you are at doing your job. Larger businesses, such as financial institutions, could be the exception to this. Truly, it?s much much more essential just to have that degree and open up your possibilities.

Cannot find a date? Explore your alternatives online. 4 out of ten couples meet online these days. It could be your substantial other is out there waiting for you to give the web a shot. Each has its excellent and poor points.

Know which values and characteristics are essential to you just before designing a plan for personal development. It?s not smart to focus on items that don?t line up along with your values and morals. Focus on positive aspects to enhance. These aspects must mesh along with your values. Adjustments to your life, in the private or professional spheres, will be easier to make permanent when they reflect your ideals.

Discover items that individuals which are successful are undertaking; use them within your personal life. Begin with some simple, easy habits, and keep in mind to practice them till it becomes second nature. You need to give your self a bit of time to make your new habit a permanent one particular. So don?t give up on it till you have continuously employed it for at least 21 days.

If the high quality level of these days is 2000, attempt to make tomorrow?s high quality level 2001 or greater. Strive for continuous and unceasing improvement. Should you did some thing quite nicely yesterday, tell yourself that wasn?t adequate. You should do it truly nicely these days.

Write your self a pep speak. List all of your excellent attributes on an index card. Put this list up on a wall, or carry it with you. You may also try videotaping your self reading your positive self-affirmations. Replay the video every day, also as whenever you must hear some positive news about your self. What excellent would this do?

Overreacting in any scenario will trigger your anxiety levels to raise. Before you turn out to be stressed, analyze the scenario. Should you make a mistake, you can often fix it or handle it. Focus more on your accomplishments as opposed to your failures.

Use these suggestions and maintain track of adjustments to your thoughts and feelings. In no way consider oneself as a failure.

These tips can assist you to increase your self-confidence and you can begin implement them even today.
Anyhow if you really want to learn how to boost your self esteem in the best way I will really suggest to get a well-known system that will teach you step-by-step how to increase your self esteem levels on the best way.

Check out these posts on 11 Forgotten Laws and Self Confidence Creator and find out about 2 popular step-by-step programs to improve your self esteem and to transform your financial life.

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Source: http://blog.javiermunoz.org/setting-goals-is-the-key-to-successful-self-improvement/

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Saturday, February 18, 2012

Whitney Houston's voice soars at hometown funeral

A coffin holding the remains of singer Whitney Houston is carried into the New Hope Baptist Church before her funeral services in Newark, N.J. on Saturday, Feb. 18, 2012. (AP Photo/Jason DeCrow)

A coffin holding the remains of singer Whitney Houston is carried into the New Hope Baptist Church before her funeral services in Newark, N.J. on Saturday, Feb. 18, 2012. (AP Photo/Jason DeCrow)

The hearse carrying the body of Whitney Houston leaves Whigham Funeral Home in Newark, N.J. for a short ride to the New Hope Baptist Church for her funeral Saturday, Feb. 18, 2012. (AP Photo/Rich Schultz)

Candles burn at a memorial at a memorial to Whitney Houston outside New Hope Baptist Church in Newark, N.J., early Saturday, Feb. 18, 2012. Whitney Houston's funeral will take place later Saturday at the church where she sang in the choir as a girl. (AP Photo/Mel Evans)

Singer Bobby Brown, left, is seen outside during the funeral of his ex-wife Whitney Houston at New Hope Baptist Church in Newark, N.J., Saturday, Feb. 18, 2012. Houston died last Saturday at the Beverly Hills Hilton in Beverly Hills, Calif., at the age 48. (AP Photo/Mel Evans)

Fans sing Whitney Houston songs as they gather a few blocks from the New Hope Baptist Church before the singer's funeral in Newark, N.J., Saturday, Feb. 18, 2012. (AP Photo/Jason DeCrow)

NEWARK, N.J. (AP) ? After all the testimonials from relatives and friends, the songs from legends and pop stars, the preaching and even laughter, the raw emotion of Whitney Houston's funeral came down to just one moment: The sound of her own voice.

As the strains of her biggest record, "I Will Always Love You," filled the New Hope Baptist Church at the end of the nearly four-hour service Saturday and her silver-and-gold casket was lifted in the air, the weight of the moment was too much for mother, gospel singer Cissy Houston, to bear.

?As she was held up by two women, she wailed, "My baby! My baby!" as she was led out the church behind her daughter's body.

A few steps behind her was the pop icon's daughter, Bobbi Kristina, also crying uncontrollably as she was comforted by Houston's close friend, singer Ray J.

It was the most searing scene on a day with mixed moods as family, friends and a list celebrities ? sometimes one in the same ? came to the humble New Hope Baptist Church where she first wowed a congregation to remember one of music's legends, but also a New Jersey hometown girl.

?Houston died last Saturday in Beverly Hills, Calif., on the eve of the Grammys at the age of 48. Her death marked the end of a life that was marked by stunning achievements: Blessed with a voice of great power and beauty, Houston became one of pop music's most successful artists over a career that spanned nearly three decades and segued into film with hits like "The Bodyguard."

?But her struggles with drugs and very public fall from grace during tumultuous times, including a union with ex-husband Bobby Brown, were among the many valleys in her life.

Both sides of Houston were recalled at the service at New Hope, which was filled with about 300 mourners, including Oprah Winfrey, Tyler Perry, Alicia Keys, Mariah Carey, Mary J. Blige, Forest Whitaker, Jennifer Hudson, Diane Sawyer and Houston's cousin, Dionne Warwick.

?"She was someone with a charmed and a beautiful life, sometimes misunderstood, even by herself," said her sister-in-law and manager, Patricia Houston. "But a life nevertheless that gave joy, happiness, enthusiasm, peace and beautiful music to millions of people around the world."

?Kevin Costner, her co-star in "The Bodyguard," said for all of Houston's beauty and success, she was still yearning for approval from the public ? and still somewhat insecure, a superstar who "still wondered, 'Am I good enough? Am I pretty enough? Will they like me?'"

"It's a tree we could all hang from ? the unexplainable burden that comes with fame," he said. "Call it doubt. call it fear. I've had mine. And I know the famous in the room have had theirs."

Many who spoke talked about Houston's unshakable faith in Jesus Christ, which got her through some of her most difficult times. Perry recalled a conversation where Houston would look sad when reflecting on her troubles, but then would hasten to add that God was taking care of her.

?"The other thing I know for sure ? and this is more important than anything that she's done in her life ? Whitney Houston loved the Lord," he said.

Fittingly, music played a major role in the send-off to one of music's greatest voices.

?Stevie Wonder rewrote lyrics to "Ribbon in the Sky" for Houston ? "you will always be a ribbon in the sky," he sang.

?So did gospel's the Rev. Kim Burrell for "A Change is Gonna Come," which Warwick said was Houston's favorite song of all time. R. Kelly brought the New Hope Baptist Church to its feet with a stirring version of "I Look to You," the title of Houston's final studio album.

?And Keys, her voice breaking at times, dedicated her song "Send Me An Angel," to Houston

Brown briefly appeared at her funeral, walking to the casket, touching it and walking out. He later said in a statement that he and his children were asked repeatedly to move and he left rather than risk creating a scene.

Close family friend Aretha Franklin, whom Houston lovingly called "Aunt Ree," had been expected to sing at the service, but said early Saturday she was too ill to attend. Franklin said in an email to The Associated Press that she had been up most of the night with leg spasms and sent best wishes to the family.

Warwick presided over the funeral, introducing speakers and singers and offering short insights about her cousin; she joked that Houston's Super Bowl performance of "The Star Spangled Banner" became almost as big as the telephone book.

Hudson, who sang "I Will Always Love You" a night after Houston's death in a Grammy tribute, mourned Houston along with Monica, Brandy, and Jordin Sparks ? representing a generation of big-voiced young singers who grew up emulating the star of the '80s and '90s. Sparks stars with Houston in the remake of the 1970s film "Sparkle," due out in August.

As the funeral began, mourners fell quiet as three police officers escorted Houston's casket, draped with white roses and purple lilies. White-robed choir members began to fill the pews on the podium. As the band played softly, the choir sang in a hushed voice, "Whitney, Whitney, Whitney."

A program featuring a picture of Houston looking skyward read "Celebrating the life of Whitney Elizabeth Houston, a child of God." Pictures of Houston as a baby, with her mother and daughter filled the program.

"I never told you that when you were born, the Holy Spirit told me that you would not be with me long," Cissy Houston wrote her daughter in a letter published in the program. "And I thank God for the beautiful flower he allowed me to raise and cherish for 48 years."

"Rest, my baby girl in peace," the letter ends, signed "mommie."

To the world, Houston was the pop queen with the perfect voice, the dazzling diva with regal beauty, a troubled superstar suffering from addiction and, finally, another victim of the dark side of fame. To her family and friends, she was just "Nippy." A nickname given to Houston when she was a child, it stuck with her through adulthood and, later, would become the name of one of her companies.

A few fans gathered hours before the service as close as they could get to the church, some from as far away as Washington, D.C., and Miami. Bobby Brooks said he came from Washington "just to be among the rest of the fans."

"Just to celebrate her life, not just her death," said Brooks, "just to sing and dance with the people that love her."

Others were more entrepreneurial, setting up card tables to sell silk-screened T-shirts with Houston's image and her CDs. Fans were kept blocks from the church and the invitation-only funeral, but their presence was felt. A huge shrine of heart-shaped balloons and personal messages that covered the street corner around the church entrance.

Houston's death marked the final chapter for the superstar whose fall from grace was years in the making. Houston had her first No. 1 hit by the time she was 22, followed by a flurry of No. 1 songs and multi-platinum records.

Over her career, she sold more than 50 million records in the United States alone. Her voice, an ideal blend of power, grace and beauty, made classics out of songs like "Saving All My Love For You," ''I Will Always Love You," ''The Greatest Love of All" and "I'm Every Woman." Her six Grammys were only a fraction of her many awards.

Her last album, "I Look To You," debuted on the top of the charts when it was released in 2009 with strong sales, but didn't have the staying power of her previous records. A tour the next year was doomed by cancellations because of illness and sub-par performances.

Houston is to be buried Sunday next to her father, John Houston, in nearby Westfield, N.J.

__

Contributing to this report were AP Global Entertainment and Lifestyles Editor Alicia Quarles and Entertainment Writer Mesfin Fekadu.

___

Online:

http://www.whitneyhouston.com

__

Nekesa Mumbi Moody is the AP's music editor. Follow her at http://www.twitter.com/nekesamumbi

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-02-18-Whitney%20Houston-Funeral/id-15f6177ac9f145ba9346ddfe876b9fc6

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Friday, February 17, 2012

Getting To Know The World Of Commercial Property Investing ...

Finding commercial real estate to buy is not exactly the same as in the residential market. Although in most markets there is a fairly abundant supply of commercial properties for sale, the listing aren?t as widely advertised as they are with residential properties. Because of this difference, knowing how to find the best available commercial real estate is critical. And since not just anybody can get access to all the prime listings, working with a top commercial real estate broker is critical as well.

The first thing to keep in mind is that buying a commercial real estate property requires a large investment in time. The process is much more complicated than buying a residential property, and it can take several weeks or even several months to find a suitable property to fit your needs.

When examining the size of the property you will need, you need to consider not just your immediate situation, but where you plan to be in the future. Most businesses have long term plans, and yours should too. But make sure the commercial office space you are considering is large enough to accommodate not only your present needs, but your future needs as well.

Another factor to look at is access to the necessary resources to make your business operate smoothly. Depending on what type of product or service you have, you may need an unusually high amount of water, electricity, or even super-fast internet speeds. The challenge is that some properties-especially in rural areas, may not be able to accommodate your utility needs. Before making a commitment to any piece of commercial real estate, talk with all the area utility companies to make sure they can provide everything your company has to have.

Now let?s talk about your commercial real estate broker. Your choice of realtor may be one of the most important decisions you make. You must be sure that you and your broker see eye to eye on exactly what you?re looking for and what you view as a successful purchase. Remember, this is the person who will be doing all the negotiating on your behalf, so you best work with someone you are compatible with.

When it comes to financing, it pays to shop around. Don?t deal with just one bank or one broker. Ask around among your friends, family, and business associates and find as many funding sources as possible. In many situations, it may be to the buyer?s advantage to seek private financing at a competitive interest rate over going through a bank. Your real estate broker should also be able to give you some good suggestions for how to deal with the financing.

Inspections are critical to the purchase of any property, but especially with commercial real estate. The problem is that some people choose to hire inspectors that are not accredited. This could lead to problems down the road if they failed to find some important issues with the property. Don?t make this mistake. When it comes time for the inspection, always make sure you?re dealing with someone who is accredited.

Source: http://www.magicmoneyclip.com/2012/02/16/getting-to-know-the-world-of-commercial-property-investing/

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